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Grace is a successful businesswoman, while Frankie is a free - spirited artist. Despite their differences, they are forced to live together and form an unlikely friendship. The show follows their journey as they navigate the challenges of aging, single life, and changing family dynamics. They experience new adventures, from dealing with their grown - up children's problems to exploring new hobbies and relationships. Along the way, they have many hilarious and heart - warming moments, supporting each other through the ups and downs. With its sharp writing, strong performances, and exploration of themes such as friendship, family, and self - discovery, Grace and Frankie offers a unique and entertaining look at the lives of two women in their later years.