The glamorous Mae West stars as a "kept" woman who flees to Alaska and the Gold Rush of the 1890s in Klondike Annie. After the beautiful Rose Carlton (West) escapes from the clutches of the wealthy and possessive Chan Lo (Harold Huber), she finds herself on a ship bound for greater pastures. The ship's captain, Bull Brackett (Victor McLaglen), instantly falls for Rose but she is distracted by her new cabin mate, Sister Annie Alden (Hele