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Led by Supervisory Special Agent Dwayne Cassius Pride (Scott Bakula), the NCIS team in New Orleans tackles cases involving the U.S. Navy and Marine Corps personnel. Their jurisdiction stretches from the Mississippi River to the Texas panhandle. The team includes ex - detective Christopher La Salle (Lucas Black), Agent Meredith Brody, ex - ATF agent Sonja Percy, IT specialist Patton Plame, medical examiner Dr. Loretta Wade, and forensics pro Sebastian Lund. Over the seasons, the team faces various challenges, from espionage and terrorism to drug - trafficking and murder. There are also changes in the team's composition, such as Brody's resignation, Percy's departure, and the addition of agents like Tammy Gregorio, Hannah Khoury, and Quentin Carter. The series not only showcases exciting crime - solving processes but also delves into the personal lives of the characters, set against the backdrop of New Orleans' unique culture and scenery.