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An anarchic, off-the-wallsci-fi family comedy with a surrealistic edge, Bug Off! opens with a pair of siblings, young Tyler and big sister Krista, constantly at each other's throats. When Krista mischievously wishes for her brother's transformation into an insect, she finds her request granted - at the hands of an extraterrestrial babysitter who calls herself Mrs. Pickle-Nickle. Krista immediately wishes him back - without success. Matters go from bug to worse when a second alien, Yendor, pops up and attempts to abduct Tyler, whisking him back to his home planet as evidence of Pickle-Nickle's malfeasance. As the situation grows bleaker, Krista must find a way to save the day and bring her long-lost brother down to Earth.