I checked the specs of your motherboard on the ASUS website, and it uses Serial ATA (SATA) 3Gb/s, as you stated. This WD HDD uses a SATA 6 Gb/s interface, but is backwards-compatible with SATA 3 Gb/s motherboards. So, yes, the drive should work with your motherboard. Also, based on the size and speed of that HDD, I highly doubt you would notice any difference in speed with it on SATA 3 Gb/s vs SATA 6 Gb/s. Hope this helps.
DISCLAIMER: It's possible for your specific motherboard and that specific HDD to be incompatible with each other. It's recommended to check the motherboard manufacturer's website for a list of compatible HDDs.