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Best Buy customers often prefer the following products when searching for ambidextrous mice.

If you're a gamer, or just someone who spends a lot of time in front of the computer, you know that having a good mouse is essential. Whether you're right or left-handed, you want something that's comfortable and easy to use. And if you're ambidextrous, you want something that works for both hands. Browse the top-ranked list of ambidextrous mice below along with associated reviews and opinions.

Main Results
  1. Logitech - POP Bluetooth Optical Ambidextrous Mouse with Customizable Emojis - Heartbreaker Rose - Front_Zoom
    Top comment

    "LOOOOOVE this mouse! It works so well and is smooth to use. It’s not as over sensitive as some other mice....My favorite mouse to use with all my Bluetooth devices...Mice heaven"

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    Product Description

    Get to know the playful, wireless POP Mouse, designed to make personality shine on your desktop and beyond. Pick the POP Mouse you love most from our range of designs, and make it your own with fun emoji customization. With SilentTouch clicks, and up to 24 months battery life, take it anywhere you go. Connect POP Mouse to your desktop, laptop, or tablet using Bluetooth on Windows, macOS, iPadOS and Chrome OS. Glide between up to 3 devices at a time with FLOW, and shift instantly from high-precision to speed scroll mode with the SmartWheel.
    See all Wireless & Bluetooth Mice
    Top comment

    "LOOOOOVE this mouse! It works so well and is smooth to use. It’s not as over sensitive as some other mice....My favorite mouse to use with all my Bluetooth devices...Mice heaven"

    See all customer reviews

    Product Description

    Get to know the playful, wireless POP Mouse, designed to make personality shine on your desktop and beyond. Pick the POP Mouse you love most from our range of designs, and make it your own with fun emoji customization. With SilentTouch clicks, and up to 24 months battery life, take it anywhere you go. Connect POP Mouse to your desktop, laptop, or tablet using Bluetooth on Windows, macOS, iPadOS and Chrome OS. Glide between up to 3 devices at a time with FLOW, and shift instantly from high-precision to speed scroll mode with the SmartWheel.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  2. Logitech - M220 SILENT Wireless Optical Ambidextrous Mouse - Off-White - Front_Zoom
    Top comment

    "Great Mouse...Great mouse does not make any annoying clicking noise....Ambidextrous Mouse...Loved the idea that it is an Ambidextrous Mouse. When I am doing something with my favored hand, I can use my other hand to scroll."

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    Product Description

    With the same click feel and 90% noise reduction compared to Logitech M170 classic mice, M220 SILENT offers a quiet experience for yourself and those around you. It has a long-lasting up to 18-month battery life with auto-sleep and a powerful 10-meter wireless range with 128-bit encryption between the mouse and the receiver. Plus, its small size is perfect to toss in a bag and go. Just plug the tiny USB receiver and it works with Windows, Mac, Chrome OS or Linux. Finally, the Logitech Advanced Optical Tracking is designed for smooth and precise moves on almost any surface.
    See all Wireless & Bluetooth Mice
    Top comment

    "Great Mouse...Great mouse does not make any annoying clicking noise....Ambidextrous Mouse...Loved the idea that it is an Ambidextrous Mouse. When I am doing something with my favored hand, I can use my other hand to scroll."

    See all customer reviews

    Product Description

    With the same click feel and 90% noise reduction compared to Logitech M170 classic mice, M220 SILENT offers a quiet experience for yourself and those around you. It has a long-lasting up to 18-month battery life with auto-sleep and a powerful 10-meter wireless range with 128-bit encryption between the mouse and the receiver. Plus, its small size is perfect to toss in a bag and go. Just plug the tiny USB receiver and it works with Windows, Mac, Chrome OS or Linux. Finally, the Logitech Advanced Optical Tracking is designed for smooth and precise moves on almost any surface.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  3. Logitech - POP Bluetooth Optical Ambidextrous Mouse with Customizable Emojis - Blast Yellow - Front_Zoom
    Top comment

    "High Vis mouse, ergonomic...Highly recommend over Microsoft mice. Great size for laptop portability...Features, functionality and price.this mouse beats all of the high priced mice. No dongle, long battery life, multiple device control."

    See all customer reviews

    Product Description

    Get to know the playful, wireless POP Mouse, designed to make personality shine on your desktop and beyond. Pick the POP Mouse you love most from our range of designs, and make it your own with fun emoji customization. With SilentTouch clicks, and up to 24 months battery life, take it anywhere you go. Connect POP Mouse to your desktop, laptop, or tablet using Bluetooth on Windows, macOS, iPadOS and Chrome OS. Glide between up to 3 devices at a time with FLOW, and shift instantly from high-precision to speed scroll mode with the SmartWheel.
    See all Wireless & Bluetooth Mice
    Top comment

    "High Vis mouse, ergonomic...Highly recommend over Microsoft mice. Great size for laptop portability...Features, functionality and price.this mouse beats all of the high priced mice. No dongle, long battery life, multiple device control."

    See all customer reviews

    Product Description

    Get to know the playful, wireless POP Mouse, designed to make personality shine on your desktop and beyond. Pick the POP Mouse you love most from our range of designs, and make it your own with fun emoji customization. With SilentTouch clicks, and up to 24 months battery life, take it anywhere you go. Connect POP Mouse to your desktop, laptop, or tablet using Bluetooth on Windows, macOS, iPadOS and Chrome OS. Glide between up to 3 devices at a time with FLOW, and shift instantly from high-precision to speed scroll mode with the SmartWheel.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  4. Logitech - M220 SILENT Wireless Optical Ambidextrous Mouse - Rose - Front_Zoom
    Top comment

    "No issues with this mouse and it looks great. Ambidextrous design doesn't seem to have any major drawbacks compared to handed mice....Good value mouse...Nice cheap mouse. It works well and is a good value compared to some of the other more expensive mice out there."

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    Product Description

    With the same click feel and 90% noise reduction compared to Logitech M170 classic mice, M220 SILENT offers a quiet experience for yourself and those around you. It has a long-lasting up to 18-month battery life with auto-sleep and a powerful 10-meter wireless range with 128-bit encryption between the mouse and the receiver. Plus, its small size is perfect to toss in a bag and go. Just plug the tiny USB receiver and it works with Windows, Mac, Chrome OS or Linux. Finally, the Logitech Advanced Optical Tracking is designed for smooth and precise moves on almost any surface.
    See all Wireless & Bluetooth Mice
    Top comment

    "No issues with this mouse and it looks great. Ambidextrous design doesn't seem to have any major drawbacks compared to handed mice....Good value mouse...Nice cheap mouse. It works well and is a good value compared to some of the other more expensive mice out there."

    See all customer reviews

    Product Description

    With the same click feel and 90% noise reduction compared to Logitech M170 classic mice, M220 SILENT offers a quiet experience for yourself and those around you. It has a long-lasting up to 18-month battery life with auto-sleep and a powerful 10-meter wireless range with 128-bit encryption between the mouse and the receiver. Plus, its small size is perfect to toss in a bag and go. Just plug the tiny USB receiver and it works with Windows, Mac, Chrome OS or Linux. Finally, the Logitech Advanced Optical Tracking is designed for smooth and precise moves on almost any surface.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  5. Logitech - M325s Wireless Optical Ambidextrous Mouse - Brilliant Rose - Front_Zoom
    Top comment

    "This is a very good wireless Optical Ambidextrous Mouse. This is my second one. I have another one just like it for another computer. "

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    Product Description

    Logitech Wireless Mouse M325s. A better mix of precision and comfort-with designed-for-Web scrolling. Designed for how you use the Web, our newest micro-precise scrolling makes everything you love to do online easier. Its feel-good, contoured shape and textured grips help keep your hand happy-even after long hours. And with up to 18 months of battery life, it virtually eliminates the hassle of changing batteries.
    See all Wireless & Bluetooth Mice
    Top comment

    "This is a very good wireless Optical Ambidextrous Mouse. This is my second one. I have another one just like it for another computer. "

    See all customer reviews

    Product Description

    Logitech Wireless Mouse M325s. A better mix of precision and comfort-with designed-for-Web scrolling. Designed for how you use the Web, our newest micro-precise scrolling makes everything you love to do online easier. Its feel-good, contoured shape and textured grips help keep your hand happy-even after long hours. And with up to 18 months of battery life, it virtually eliminates the hassle of changing batteries.
    See all Wireless & Bluetooth Mice
    See all Wireless & Bluetooth Mice
  6. HP - X3000 G2 Wireless Optical Ambidextrous Mouse - Black - Front_Zoom
    Top comment

    "Mouse...Great mouse...Ambidextrous Mouse"

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    Product Description

    An ambidextrous travel-sized wireless mouse with long battery life. Improve the way you connect and communicate, work and play. Built with strict HP standards and guidelines, this world-class HP Wireless Mouse X3000 G2 effortlessly blends sleek, modern design with life-enhancing, advanced features.
    See all Ergonomic Mice
    Top comment

    "Mouse...Great mouse...Ambidextrous Mouse"

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    Product Description

    An ambidextrous travel-sized wireless mouse with long battery life. Improve the way you connect and communicate, work and play. Built with strict HP standards and guidelines, this world-class HP Wireless Mouse X3000 G2 effortlessly blends sleek, modern design with life-enhancing, advanced features.
    See all Ergonomic Mice
    See all Ergonomic Mice
  7. ROCCAT - Kone XP Wired Optical Gaming Ambidextrous Mouse with multi-button design & AIMO RGB lighting - Black - Front_Zoom
    Top comment

    "Great mouse almost perfect....One of the best mice I've ever used, I love it, the side buttons are a bit cheap feeling but overall the mouse does everything I need it to. ...KONE XP: Another stellar ROCCAT Mouse...The build quality of this mouse is premium. I absolutely love how the implement the plastic on their mice. "

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    Product Description

    The ROCCAT Kone XP 3D Lighting Gaming Mouse utilizes the refined ergonomics of the iconic Kone shape. The translucent shell sets the stage for the Kone XP’s 22 LEDs and 8 light guides, creating an unprecedented and immersive lighting experience. The Kone XP boasts 15 buttons, and thanks to ROCCAT’s Easy-Shift[+] duplicator technology there are 29 possible button functions. Ideal for gamers who demand deep customization. The Krystal 4D Wheel not only adds to the number of inputs, but also enhances the experience, beautifully diffusing the RGB lighting..
    See all Gaming Mice
    Top comment

    "Great mouse almost perfect....One of the best mice I've ever used, I love it, the side buttons are a bit cheap feeling but overall the mouse does everything I need it to. ...KONE XP: Another stellar ROCCAT Mouse...The build quality of this mouse is premium. I absolutely love how the implement the plastic on their mice. "

    See all customer reviews

    Product Description

    The ROCCAT Kone XP 3D Lighting Gaming Mouse utilizes the refined ergonomics of the iconic Kone shape. The translucent shell sets the stage for the Kone XP’s 22 LEDs and 8 light guides, creating an unprecedented and immersive lighting experience. The Kone XP boasts 15 buttons, and thanks to ROCCAT’s Easy-Shift[+] duplicator technology there are 29 possible button functions. Ideal for gamers who demand deep customization. The Krystal 4D Wheel not only adds to the number of inputs, but also enhances the experience, beautifully diffusing the RGB lighting..
    See all Gaming Mice
    See all Gaming Mice
  8. Kensington - Orbit 72337 Optical Gaming Ambidextrous Mouse with Scroll Ring - Black and Blue - Front_Zoom
    Top comment

    "Best scolling mouse of any kind....Dust, grit, etc. mess up optical mice including trackballs. The ball lifts out, and a cleaning wipe athen replace ball only takes seconds. ...This is a nice ambidextrous Trackball, but the Middle/Drag button setting doesn't always work well with SolidWorks. "

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    Product Description

    All-day comfort and scrolling come together in the Kensington Orbit Trackball with Scroll Ring. The scroll ring allows you to fly through web pages and documents. And all while delivering comfort and space savings no mouse can match.
    See all Ergonomic Mice
    Top comment

    "Best scolling mouse of any kind....Dust, grit, etc. mess up optical mice including trackballs. The ball lifts out, and a cleaning wipe athen replace ball only takes seconds. ...This is a nice ambidextrous Trackball, but the Middle/Drag button setting doesn't always work well with SolidWorks. "

    See all customer reviews

    Product Description

    All-day comfort and scrolling come together in the Kensington Orbit Trackball with Scroll Ring. The scroll ring allows you to fly through web pages and documents. And all while delivering comfort and space savings no mouse can match.
    See all Ergonomic Mice
    See all Ergonomic Mice
  9. Microsoft - Wireless Bluetooth Optical Ambidextrous Mouse - Glacier - Front_Zoom
    Top comment

    "This is the quality Microsoft mouse you would expect. Being left-handed, the ambidextrous mouse is great. ...I always use MS mice with my laptops, both MacOS and Windows. My new MacBook has USB-C instead of USB-A ports, so I bought this bluetooth mouse. "

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    Product Description

    Meet your new go-to mouse for precise scrolling and navigation across documents and web sites. The modern, compact design fits comfortably in your hand and makes it easy to be productive on the move with smooth tracking on most surfaces. Complement your style and your Windows laptop with a choice of colors. Plus, stay connected and in your flow with wireless Bluetooth 5.0 LE and up to 12 months of battery life.¹
    See all Microsoft Surface Mice
    Top comment

    "This is the quality Microsoft mouse you would expect. Being left-handed, the ambidextrous mouse is great. ...I always use MS mice with my laptops, both MacOS and Windows. My new MacBook has USB-C instead of USB-A ports, so I bought this bluetooth mouse. "

    See all customer reviews

    Product Description

    Meet your new go-to mouse for precise scrolling and navigation across documents and web sites. The modern, compact design fits comfortably in your hand and makes it easy to be productive on the move with smooth tracking on most surfaces. Complement your style and your Windows laptop with a choice of colors. Plus, stay connected and in your flow with wireless Bluetooth 5.0 LE and up to 12 months of battery life.¹
    See all Microsoft Surface Mice
    See all Microsoft Surface Mice
  10. SteelSeries - Sensei Ten Wired Optical Gaming Ambidextrous Mouse - Black - Front_Zoom
    Top comment

    "Best mouse....Ive used this style of ambidextrous mouse since 2012, and i cant use any other. having buttons on both sides of the mouse is great for gaming....It's a good mouse!...This is the best ambidextrous mouse out right now from an intelli 1.1a mouse user. "

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    Product Description

    The Sensei Ten is a competitive gaming mouse built for lasting performance. It carries on the historic Sensei legacy with an iconic ambidextrous shape, and adds all-new upgrades like a sleek new finish, hyper durable materials, a TrueMove Pro 18,000 CPI sensor, and a 60 million click guarantee.
    See all Gaming Mice
    Top comment

    "Best mouse....Ive used this style of ambidextrous mouse since 2012, and i cant use any other. having buttons on both sides of the mouse is great for gaming....It's a good mouse!...This is the best ambidextrous mouse out right now from an intelli 1.1a mouse user. "

    See all customer reviews

    Product Description

    The Sensei Ten is a competitive gaming mouse built for lasting performance. It carries on the historic Sensei legacy with an iconic ambidextrous shape, and adds all-new upgrades like a sleek new finish, hyper durable materials, a TrueMove Pro 18,000 CPI sensor, and a 60 million click guarantee.
    See all Gaming Mice
    See all Gaming Mice
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