This game has been out on other platforms for quite some time, however this new version for switch is fantastic. This includes the remake/remaster Rebirth, as well as both of the current DLC packs: Afterbirth and Afterbirth+.
The game itself is somewhat difficult to explain... at its heart, Isaac is a dungeon crawling game. Unlike many games nowadays, when you die you lose everything and start over from the first floor of the dungeon, with the dungeon changing every time. And trust me, you will die. To help you along the way, you find items that usually help, but also may sometimes hinder you. With hundreds of items available, a large part of the fun is finding new items, discerning what they do, and then how they interact with other items.
For instance, a bent spoon will psychically guide your shots towards enemies, and a robotic eye will exchange your shots for a laser; combined, you now have a laser that twists and turns to run through enemies. There is an item that causes you to explode when you use it, damaging both yourself and objects around you, and another object that causes explosions to heal you; together, you are able to heal yourself as well as just walk up to enemies and begin blowing them up.
The subject matter is not light. Your character is a crying child named Isaac, who is running away from his mother after she has been commanded by God to kill Isaac. The items, enemies, bosses, etc all revolve around death, filth, religion, abortion, and drug paraphernalia. This is not intended for children, despite the game being available on a Nintendo platform.
As I mentioned before, each time you die you restart the game. However, not all is lost every time. Each time you go through the dungeon, as you kill more bosses, pick up more items, defeat more enemies, etc. you are making progression, unlocking more floors to be available and more items can show up, as well as a litany of characters to play as on future runs. There are also many convoluted ways to beat the game for those that enjoy it enough to seek them out.
The switch only makes this game better, able to take it on the go on the fly, drop-in and drop-out co-operative gameplay for up to 4 players, and able to simply place the console to sleep to continue later (a "run" through the dungeon can sometimes take up to an hour). It is very pick up and play friendly, as depending on your skill and luck you could blow through a run in 20 minutes or less. I do notice some technical issues that I did not experience when playing on the Vita (Rebirth only, this version is my first experience with the DLCs). For instance, there is an item called "No. 2" that causes you to drop a fecal bomb (told you it can be gross...) after firing for 5 consecutive seconds. When that bomb explodes, a cloud covers the current room you're in, damaging all enemies. When that or other full-screen effects happen, the framerate dips dramatically. It is sort of helpful in the moment to moment gameplay, as you are able to dodge attacks almost like you're Neo from The Matrix, but it is not intended and is most certainly a performance issue. I have also had an issue with a particular enemy's AI, where it will jump to the corner of the room and just sit there. Sometimes there are rocks in that corner, and I do not have a way to get to the enemy to kill it, locking me in that room. The game has a built-in fail-safe for events like this, opening the room after no damage is done to either enemy or player after so much time. Still, what fun is it to sit there and wait 1 or 2 minutes doing nothing? You also do not get a reward for clearing the room, and have to redo the room if you end up having to walk back through.
Those issues aside, I have had a great time with the game on the Switch. I recommend looking up videos of the gameplay before diving in head-first, but if you like what you've read then I say take the leap.