Unsurprisingly, Dead Rising 2 has a great deal in common with the first game of the same name. The setting is a fictionalized (but realistic) Las Vegas, in a massive, zombie-overrun development similar to the real City Center, called Fortune City. The complex is comprised of about four major casinos and several smaller ones, with a hotel, restaurants, underground access tunnels, and of course... an enormous shopping mall.
The main character is Chuck Greene, a motocross superstar whose daughter Katey has been bitten - by her mother it turns out - and is in danger of becoming a zombie. Chuck has to provide her with a rare and expensive drug called Zombrex at exact 24 hour intervals, but at the start of the game he doesn't have any. Thus, he must venture out into the seething mass of unhumanity, smashing, chopping, shooting, bashing, blasting, lawn-mowering, punching and kicking his way through the zombie crowds, in search of the medicine that will let his girl remain a little girl.
Meanwhile, someone has framed Chuck as the cause of the zombie outbreak. He must thwart looters and psychopaths, rescue survivors and lead them to safety, and gather the evidence that will prove his innocence - all while searching for Zombrex and contending with strife among the survivors.
In terms of game play, this is exactly the same as the first Dead Rising game. The only significantly new mechanic is the ability to combine items and make combo weapons. For example, take a baseball bat and add nails - you have a spiked bat. Take a bottle of vodka and add a newspaper - instant Molotov. Take a vacuum cleaner and add saw blades, and you get The Exsanguniator. The possibilities are impressively vast, brutal and lethal.
This sequel includes an enormous, labyrinthine safe house area where Chuck must lead the survivors he finds. A love-interest (his wife is dead, remember?) stays in the security room watching Katey and providing him tips on where to find survivors (and sometimes Zombrex) using a two-way radio. There are literally dozens of survivors to find; it seems like there are far more than in the first game. Not all of them want to be saved, or in some cases they won't follow Chuck unless he meets their conditions (e.g., rescue my loved ones first). This game also has way more psychopaths to fight than the first, and almost all of those fights are entirely optional.
Rescuing survivors and defeating psychopaths earn Chuck experience in the form of Prestige Points, which he uses to level up. Gradually, Chuck becomes stronger, faster, and better able to defend himself (even unarmed, using a variety of pro-wrestling moves); plus he can expand his capacity to carry food and weapons, and learn new weapon combinations.
As with the first game, every survivor - and every major plot point - has a limited shelf life, and it's very easy to run out of time on anything, just wandering, smashing zombies, and exploring the vast complex. There are plenty of hidden goodies (such as Zombrex just lying around in hard-to-reach places) and looters have set up several "pawn shops" where Chuck can buy weapons and supplies. But just like the first game, if you fail to complete anything in time, you can always start over from the beginning of the story and take all of your experience, levels, and unlockable items (such as keys) with you back to the start. (You'll probably want to do this at some point.)
One other note – Xbox Live offers a brief DLC prequel that was released prior to this game, called Dead Rising 2: Case Zero. The setting is a small town in Nevada (on the way to Vegas) and you can carry over character skills and upgrades from the prequel to the full game. If you have an Xbox 360, it’s worth choosing the Xbox version of this game just so you can play the prequel and continue on into the main game.
Dead Rising 2 is a vast, exciting, nick-of-time adventure that's endlessly bloody and brutal, as a father strives to keep his daughter alive, clear his name, and rescue innocent bystanders. If you liked the first game, you'll love this. If you haven't played the first game but you enjoy zombie-themed entertainment (think Dawn of the Dead 2004), this game is definitely for you.