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Yes, the Acer Nitro 60 N60-180-UB33 desktop can handle a 5.1 surround sound speaker system, but primarily through digital connections rather than analog. It features 802.11ax Wi-Fi, Bluetooth 5.4, HDMI 2.1, and DisplayPort, allowing for 5.1/7.1 audio over HDMI to a receiver or via USB/Bluetooth for compatible surround speakers.
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