A:AnswerYes but a universal still needs to be programmed to some extent. The harmony is going to dupicate the BASIC functions of the AV remote. Just reprogram your Harmony with the new device ID number. I said basic, it will not do everything that the AV remote will do. I assume you already have a Harmony so you know the drill in setting it up. Be advised, Logitech is dropping the Harmony remote business line. They say they will still support it but I'm not sure what that exactly means. I have a Harmony 600 to provide RF to IR so I can hide all my components. I bought an extra remote off ebay to extend the life of my remote set up. Oops. I'm rambling.