A:Answer Yes, however, bear in mind you won't be able to upgrade your CPU to comet lake CPU's and above, also unless I'm mistaken, it doesn't support PCI-E gen 4 which might minorly affect performance. If you're going to splurge on a motherboard, I recommend getting one that can support the new generation of CPU's coming out, so if you want to upgrade you don't have to buy a whole new expensive board.
If you already have this motherboard and are just looking to upgrade your GPU, it will work fine, with only the most minor of performance flaws.