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Hi Mike! Yes, Sage 50 US Premium Accounting 2022 will run on Windows 10. Please use this site (https://www.sagecity.com/global-resources) to get to the Sage 50 US Knowledgebase and type kb number 111569 in the search box for System Requirements: Sage 50—U.S. Edition 2022 (111569), which will give you all the system requirements for Sage 50US Accounting 2022. I hope this information has been helpful! MC-
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