YES. The most significant one I've found so far (after owning them for 2 days) is that you can only control the volume completely if wearing BOTH. The left one controls the "down" volume and the right one controls the "up". I was very confused at first but finally figured out the very unhelpful user manual's hieroglyphics! For the record, the user manual leaves a LOT to be desired, especially for the older generations that may be a wee bit technologically impaired, lol. Unfortunately, it's kind of a necessary evil, as they both have / need the pause, play, skip (for music), plus the answer / decline call capability - they can only fit so many buttons on each earbud. You can still control the volume with the buttons on your phone though. Hope this helps!