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Thank you for reaching out Greg. Any motherboard should be able to hold any types of graphics card. The thing that makes the difference is how big your case is because some video cards are bigger than others so you need to make sure it can fit and how much wattage you need in order to run said video card. Depending on the card, you may need to upgrade your power supply as well. If you have any further questions or concerns then please do not hesitate to give our tech support agents a call for any assistance; we're always happy to help. Tech support: (888)937-5582 - CyberpowerPC Support
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