A:AnswerBen,
It will depend on the in-game settings and your monitor's resolution. This PC can play Fallout 4 modded if you have the settings dialed in appropriately.
Thanks,
A:AnswerReason it runs loud is because the top switch on the left is pushed towards the back of the computer which is the high speed for the case fan. move it to the front of your computer and the rear case fan will slow. Then your computer will be quiet. When using your computer I recommend it be set to high speed for better cooling.
Bill8
A:AnswerJosh,
There are quite a few pictures of this build available online if you do a search for the CybertronPC Rhodium GTX Desktop, which will answer your USB questions.
Thank you,