A:AnswerIndex cards are generally 110 pound which is a bit heavy for this design of printer. It can handle the size, but ... if they are standard heavy index card stock, I would look at a backfeeder printer such as the OfficeJet 3830.
A:AnswerYes, Instant Ink is optional. It saves a lot of money on ink and is very convenient, but you can always buy cartridges the standard way if you prefer.
A:AnswerYes, you can load multiple pages in the Automatic Document Feeder, they will pass through the scanner and allow you to copy/scan multiple pages at once.
A:AnswerYou will be amazed when this printer simply sets all that up for you after you plug it in. You watch and select your preferences. click the language you want, fax, answering machine and several other options. I have never found this on any other printer. It takes minutes to set it up.