A:Answer Depends on what you mean by ‘work with.’ The Amp is for when you want to may your own non-Sonos, wired, unamplified speakers, not for direct use with the any of Sonos Speakers. However, as with any Sonos product you could play music with your separately purchased speakers through your Amp and a Sonos One simultaneously by placing it in a different room and running them concurrently.