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Hi BigBoi! Thank you for inquiring about our Insignia™ - 3-Device Universal Remote. Yes, this remote should be compatible with your E320-B2. Let us know if you need further assistance. Have a nice day! - James | Insignia Support | https://www.bestbuy.com/site/insignia-3-device-universal-remote-black/6495829.p?skuId=6495829
Sorry, there was a problem. Please try again later.Hi BigBoi, Thank you for your interest on our product Insignia™ - 3-Device Universal Remote - Black. Yes the remote was made to be compatible with Vizio tv even with the model number you provided. Just make sure to follow the User Manual Guide in connecting the remote properly. Jona | Insignia Support. https://www.bestbuy.com/site/insignia-3-device-universal-remote-black/6495829.p?skuId=6495829
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