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Thank you for your inquiry! The Insignia Replacement Remote for LG TVs connects to Netflix and Prime by syncing with your LG TV. It should work with the LG 43Nano75UPA, as it is designed to be a replacement remote for LG TVs. Typically, you should not have to change anything in the TV settings to make it connect and function properly. Simply pair the remote with your TV using the instructions provided and you should be ready to go. Keith | Insignia Support https://www.bestbuy.com/site/insignia-replacement-remote-for-lg-tvs-black/6448218.p?skuId=6448218
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