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The Nest thermostat is accessed thru Wifi (which is radio frequency or RF). This logitech is IR (infra-red) only, which means it can handle 98% of the AV devices out there. This model cannot handle most of the current crop of network streaming devices such as Amazon Fire or Roku. There are a few network streaming devices that can be operated by both RF and IR and then this unit will work.
Sorry, there was a problem. Please try again later.Short Answer...YES... https://support.myharmony.com/en-us/harmony-experience-with-nest-thermostat
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