A:Answer I don't see why it should not work. I use it with a motorola QIP7100/6386/010 VERIZON box, a Samsung 4k tv, and a jbl cinema sb400 soundbar. On the soundbar, the harmony gave me a bluetooth button, while the original jbl remote did not. Watch the ARC and Anynet settings. You may need to turn them off since they will also try to turn you devices off/on. To listen to soundbar music without the tv, i had to run an optical cable from cable box to soundbar.