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No. The Nikon AF-S NIKKOR 200-500mm f/5.6E ED VR lens has an electromagnetic diaphragm mechanism in the lens barrel which will not communicate fully with the Nikon D80. This camera model is fully compatible with AF-S and AF type lenses, like the AF-S NIKKOR 80-400mm f/4.5-5.6G ED VR Telephoto Zoom Lens. Please check your camera's manual or contact Nikon Support for further details on lenses that are compatible with the D80.
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