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Hello Dwayne! Absolutely, you'll be able to control the sound of your Samsung t650 sound bar with the Harmony 665 10-Device Universal Remote. You can check compatibility for all your devices with all the Harmony remotes here: https://support.myharmony.com/en-us/compatibility#
Sorry, there was a problem. Please try again later.You should be able to use this with your setup. I have my Samsung tv, a cable box, a DVD player and a Bose 3-2-1 GSX speaker system that are all controlled by the 665.
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