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According to the website, the Harmony 66# (noon-hub based) remotes can not control the Amazon Firecube. The hub-based Harmony remotes can but they are considerably more pricey.
Sorry, there was a problem. Please try again later.Hello AKgirl, Unfortunately, the Harmony 665 isn't compatible with the Amazon Fire TV Cube, but Harmony Hub-based Remotes are. Here's a list for you to check them out: https://www.logitech.com/en-us/products/harmony.html?filters=hub-based-remotes. - Richard from Logitech
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