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Harmony 665 will work just fine with your Bose Lifestyle system! Check out the compatibility of Harmony remotes with any of your other systems here https://support.myharmony.com/en-us/compatibility
Sorry, there was a problem. Please try again later.Absolutely this will work for you as long as you have the exact Model Number. In some instances if there are multiple Model Numbers within the same series you may need to switch it until you find the one that works all of your features. I got mine to work with both a $25.00 dollar store oscillating fan, But also a $5.00 strip of generic no name LED lights, Lol. So yes it will work.
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