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If the speakers are controlled by the Roku TV, then yes.
Sorry, there was a problem. Please try again later.Hello Ben! IR (Infrared) remotes such as the Harmony 665 10-Device Universal Remote can only control speakers with IR capabilities (i.e. for Sonos, IR remotes such as the Harmony 665 are only able to control Sonos ARC, Beam, PLAYBAR, and PLAYBASE).
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