A:Answer You don't provide much detail about your TV or or PVR/DVR configuration, but in general, you can use the Logitech MyHarmony setup software to "teach" the 650 any button on your device's original remote, and you can use the MyHarmony software to create custom command sequences that you can then map to any button on the 650. For example, I created a custom command sequence on the 650 to jump to the Plex channel on my Roku box with a single press of a button. Hope this helps.
