A:AnswerYou can drill holes in anything and I would guess you could drill holes in this stand also. Keep in mind, the hole won't be re-enforced like a factory formed hole would be so I'd use large washers so the screws wouldn't pull through or crack the plastic.
A:AnswerYes, I am using a Fire stick with this TV. I subscribe to streaming TV channels and it works fine. I use the remote that came with the fire stick so I can use voice commands.