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I believe so as long as you're on a laptop or computer (because of the usb port). The headset really just acts as another microphone and speaker than the one bulit into your computer. It comes up as "logitech speaker/headset" when I change any settings. I would make sure that these settings in Skype match what you want.
Sorry, there was a problem. Please try again later.Yes, the H600 headset will work just fine with Skype.
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