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Yes, you can use up to 3 M.2 NVME drives. The board even supports hardware RAID of M.2 SSDs. To use a M.2 drive as your boot drive, (the drive windows is loaded to and runs from), you will need to enter the Bios and configure the motherboard to do so. Many YouTube videos are published for this motherboard and it easy a simple process.
Sorry, there was a problem. Please try again later.Yes, this board supports two M.2 drives with that CPU. The complete specifications can be found here. https://www.asus.com/us/Motherboards/ROG-STRIX-B450-F-GAMING/specifications/
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