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Thanks for reaching out Isaac. As long as the NZXT M22 supports the socket, it should work fine. As for the GTX 1660, the AMD FX-6300 may potentially bottleneck it, however, you will upgrade your PSU to one that supports the power connector. If you have any further questions or concerns then please do not hesitate to give our tech support agents a call for any assistance; we're always happy to help. Tech support: (888)937-5582 -CyberpowerPC Support
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