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Thanks for reaching out nickjohnson. As long as the motherboard has a PCI-E x16 slot, it should work on any PC. The only socket would be for your CPUs as they use different socket types. If you have any further questions or concerns then please do not hesitate to give our tech support agents a call for any assistance; we're always happy to help. Tech support: (888)937-5582 -CyberpowerPC Support
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