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As long as the receiver in your USB slot can receive the signals from the keyboard and mouse, you should have no problems.
Sorry, there was a problem. Please try again later.Hello Marg, Yes, the MK270 Wireless keyboard and mouse will work with your desktop. Driver/software downloads are available on the Logitech website to get the full experience. Enjoy! - John https://www.logitech.com/en-us/product/11052
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