A:AnswerYes, this Anker charger can charge an iPhone SE (that's the phone I have too). No issues and speeds up charging time noticeably. You just need a USB-C cord with one end being the lightning tip used by Apple.
A:AnswerYes, however you would need to buy a different cable then what’s in the box… the iPhone SE second gen comes with USB-A to lightning but you would need to get a USB-C to lightning.