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That would depend on the physical dimensions of your 3080 model. You most likely would need to replace the power supply as well. For troubleshooting help, please reach out to ASUS Support either by phone, chat, or email. https://www.asus.com/support/ You can also find us on Twitter @AsusHelpUS.
Sorry, there was a problem. Please try again later.I checked the specs for both video cards and the 2080S uses a PCI-E 3.0 interface while the 3080 uses a PCI-E 4.0. It might fit in the slot but you would likely not get the full speed and functionality it could otherwise offer. I recommend you check the motherboard specs for this system to see if 4.0 is an available slot on it.
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