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Thanks for reaching out Jadenrino. This motherboard should be able to support any GPU, just beware you will need to upgrade your power supply depending on how high you upgrade. As for the RAM, it varies with the motherboard. This motherboard should only support up to 32 GB of DDR3 1600 Mhz ram. If you have any further questions or concerns then please do not hesitate to give our tech support agents a call for any assistance; we're always happy to help. Tech support: (888)937-5582 - CyberpowerPC Support
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