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Technically it is possible. You would very likely be much happier with the results if you clean-installed Windows 10 rather than inheriting all the registry and file bloat that your old installation has accumulated, plus likely several Upgrades. These can all have the effect of slowing the system compared to new. If you don't have someone to help you do this, you can at least try using the SSD and see how well you feel it works. You can always clean-install later. The safest place to start is with a complete backup before you clean-install. If your ASUS is Windows 10 Home, this Dell has a Windows 10 Home license in its BIOS. If your ASUS is Windows 10 Professional, putting the SSD in the Dell won't actually work because the Windows install on your SSD won't match the "license key" in the Dell's BIOS. If they both have HOME, then before you switch hard drives, on the ASUS, you should go download the DELL WiFi drivers, from support.dell.com, and you can enter the service tag from your Dell to get to exactly the correct drivers, for Windows 10 64-bit. Download and save the Dell WiFi drivers so they are there in case you need to install them yourself after switching the SSD into the Dell. On your DELL, google and grab a utility called ShowKeyPlus. I recommend the download from MajorGeeks as I've never had malware or spyware slipped into any download from MajorGeeks. The current version as of today is ShowKeyPlus 1.0.6594 Extract and run ShowKeyPlus on your DELL, which will show you the OEM Key in the BIOS. You will need to write down or save this key somewhere so you can enter it later. After you switch to the ASUS SSD, it will do a lot of updating to get the drivers for the new hardware, and reboot possibly more than once. You may have to install the WiFi drivers yourself, as the ASUS may not have WiFi drivers that work on the Dell. To activate Windows 10, you will have to go into Settings, Update, Activation, and Change Product Key. Then you will have to enter the DELL OEM Key you got earlier, so the ASUS's Windows 10 gets re-activated with your DELL Windows 10 OEM key. You may have to uninstall ASUS specific things that no longer apply to the Dell.
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