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Hello TurnbullBoys, Yes, the Logitech MK270 Mouse and Keyboard combo is compatible with the HP EliteDesk. The MK270 uses one USB Nano receiver to communicate with the mouse and keyboard. I have attached a link to the “Getting Started” support page for the Logitech MK270 for your reference, here you will find specifications and software downloads. I recommend downloading the “SetPoint” software for customization and updates. Please feel welcome to visit the Logitech website for product support. Best regards, John at Logitech https://support.logi.com/hc/en-us/articles/360024158874--Getting-Started-Wireless-Combo-MK270
Sorry, there was a problem. Please try again later.Yes just plug the dongle in and go.
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