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Yes with some requirements. It has to be a Logitech mouse and that mouse has to be compatible with Logitech's Unifying receiver which is usually most of their devices above the lowest end. A Google search for "Unifying software download" will take you to the software download page. For example, I am using this keyboard with my Logitech M570 trackball after I connected the trackball to the included receiver using that Unifying software application.
Sorry, there was a problem. Please try again later.Hello, The MK540 uses a Unifying Receiver that connects both the keyboard and mouse. If your mouse is a Logitech one that also uses the Unifying Receiver, than you can most certainly use it together with the MK540's keyboard. You'll need to use Logitech's Unifying Software to pair your mouse with the receiver. Here's the link to the download: https://support.logi.com/hc/en-us/articles/360025297913. - Richard from Logitech
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