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Download the software from Logitech for the mouse. On Mac's, it creates an app which you'll need to open. Once the app is open, click on the image of your mouse, then click on each of the side buttons and choose what you'd like to have that button do.
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Sorry, there was a problem. Please try again later.To program the side buttons on your Logitech Signature M650 L mouse, you'll need to use Logitech Options+ software.
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