Yes it will work with any USB device with an OS which allows external storage however, depending on the OS the device your plugging into has it may reformat the drive...or at least require you to do so. In the case of expanding a DVR's storage capacity, most DVR's do not run a Windows OS therefore will typically auto reformat the drive. One thing to keep in mind, due to piracy laws, you cannot simply remove it from one DVR and plug it into another expecting that have access to your previously recording content, the new DVR will automatically reformat the drive. This is by design due to Piracy. Imagine recording the entire Game of Throne series, copying it to multiple hard drives?? imagine the amount you could sell those drives for. This is the reason DVR's are configured to automatically reformat any new Drive detected.