Upgrade to smarter scrolling, better comfort, and more productivity with the Signature M650 L. The versatile mouse features an adaptive scroll SmartWheel that delivers line-by-line precision, and auto-switches to super-fast free spin mode with the flick of a finger. A choice of sizes for smaller, larger and left hands means there's a perfect fit for anyone. Seamless wireless connectivity, customizable side buttons, and a comfort shape keep you comfortably and productive hour after hour. Logitech’s SilentTouch technology delivers silent clicks to keep you focused – while the up to 24-month battery life and universal operating system compatibility ensure hassle-free performance.
A: Hey there Paul. The M650 has a ratcheted scroll wheel, so it should be tighter than that of the M325.
A: You can hold it in either hand (I just tried it right now), and it doesn't feel awkward, although the side buttons will remain on the left side of the mouse, instead of where your thumb would be. Also, the Primary and Secondary mouse buttons (left and right click) would stay where they are, unless you use the Logitech software to remap and swap left and right click. TL;DR It doesn't feel awkward, but buttons and layout isn't specifically designed for left-handed people.
A: It’s definitely not necessary because I’ve been using it without one, but it’s also not a bad thing to have.
Q: What is the switch on the left side for?
A: Use to advance ahead.
A: No plug-in Adapter needed
A: Fits any size of hand correctly
Q: How do I program the side buttons?
A: Download the software from Logitech for the mouse. On Mac's, it creates an app which you'll need to open. Once the app is open, click on the image of your mouse, then click on each of the side buttons and choose what you'd like to have that button do.

Upgrade to smarter scrolling, better comfort, and more productivity with the Signature M650 L. The versatile mouse features an adaptive scroll SmartWheel that delivers line-by-line precision, and auto-switches to super-fast free spin mode with the flick of a finger. A choice of sizes for smaller, larger and left hands means there's a perfect fit for anyone. Seamless wireless connectivity, customizable side buttons, and a comfort shape keep you comfortably and productive hour after hour. Logitech’s SilentTouch technology delivers silent clicks to keep you focused – while the up to 24-month battery life and universal operating system compatibility ensure hassle-free performance.

Upgrade to smarter scrolling, better comfort, and more productivity with the Signature M550 – featuring SmartWheel scrolling that delivers precision and speed in an instant. A choice of sizes for smaller or larger hands means there's a perfect fit for anyone. Seamless wireless connectivity, silent clicks, and a comfort shape keep you comfortable and productive hour after hour.

With the same click feel and 90% noise reduction compared to Logitech M170 classic mice, M220 SILENT offers a quiet experience for yourself and those around you. It has a long-lasting up to 18-month battery life with auto-sleep and a powerful 33 ft wireless range with 128-bit encryption between the mouse and the receiver. Plus, its small size is perfect to toss in a bag and go. Just plug the tiny USB receiver and it works with Windows, Mac, Chrome OS or Linux. Finally, the Logitech Advanced Optical Tracking is designed for smooth and precise moves on almost any surface.

G305 features the next-gen HERO sensor with 12,000 DPI sensitivity and LIGHTSPEED wireless 1 ms performance. It’s long-lasting with 250 gaming hours from one AA battery (an indicator light reminds you before you need a new AA), ultra-portable with built-in nano receiver storage, lightweight weighing in at 99 grams, and ready to game with 6 programmable buttons. G305 is the LIGHTSPEED wireless mouse for all.
| Pros for Logitech - Signature M650 L Full-size Wireless Optical Scroll Mouse with Silent Clicks - Wireless - Graphite | |||
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| Cons for Logitech - Signature M650 L Full-size Wireless Optical Scroll Mouse with Silent Clicks - Wireless - Graphite | |||
Customers are enthusiastic about the Signature M650 L mouse, particularly its ease of use and comfortable size. Many appreciate the convenience of Bluetooth connectivity and the quietness of the silent clicks. While the side buttons are not silent, users are generally satisfied with the mouse's ergonomics, long battery life, and overall performance.
The vast majority of our reviews come from verified purchases. Reviews from customers may include My Best Buy members, employees, and Tech Insider Network members (as tagged). Select reviewers may receive discounted products, promotional considerations or entries into drawings for honest, helpful reviews.
I absolutely LOVE this mouse. The larger size is so comfortable in my hand and I absolutely LOVE that it connects by Bluetooth and does not require a dongle of any sort attached to my computer (although it comes a micr-sized dongle if, for some reason, you choose that option). You have the option of downloading Logi software to reprogram the buttons and side buttons if you wish, or you can simply connect it and use it quickly and easily as it is. I also love the fact that multiple colors are available. I have three different colors for three different computers, and I have two connected to each computer - one at home and one at the office, so I simply open my laptop and get to work instantly without carrying mice around. You should buy this mouse. It’s the best one I’ve ever owned. And for those with smaller hands, the same mouse is available in a smaller version without the “L” at the end of the model number. (“L” stands for “Large”). I got my wife that version and she loves it!
Posted by DavidC
I recently purchased this Logitech full-size wireless optical scroll mouse, and I must say, it's been a fantastic addition to my setup! One of the standout features for me is the silent click functionality. As someone who often works in quiet environments, whether it be a library or a home office, the ability to click without making noise is a game-changer. The design of the mouse is sleek and ergonomic, making it comfortable for long hours of use. The optical scroll is smooth and responsive, allowing for effortless navigation through documents and web pages. The wireless feature also adds a level of convenience, as there are no tangled cords to worry about. Battery life has been impressive so far, lasting several weeks on a single charge, which is a significant plus in my book. Overall, if you're looking for a reliable and quiet mouse, this wireless optical scroll mouse is worth considering. It enhances productivity without disturbing those around you, truly merging functionality with a peaceful workspace!
Posted by TINAW
I’ve been using the Logitech Signature M650 L for a few weeks, and I’m thoroughly impressed. This mouse is designed for larger hands, and it fits perfectly—making it incredibly comfortable for extended use. The scrolling is smooth and responsive, and I love the SmartWheel feature that switches between precise and fast scrolling effortlessly. The clicks are whisper-quiet, which is great for working in quiet environments like libraries or shared offices. Connectivity is flawless. You can connect it via Bluetooth or the included Logi Bolt USB receiver, and both methods are stable with zero lag. It’s also plug & play, so setup was instant. The battery life is excellent, and the overall build feels sturdy and premium. Whether you're working, studying, or browsing, the M650 L delivers excellent performance and comfort. If you’re looking for a reliable and ergonomic wireless mouse for everyday use, the Signature M650 L is a fantastic choice.
Posted by AmarelyS