A:AnswerFirst off I dont recommend targus brand. Second most usb hubs have problems with ps4 and xbox. If you have to use one try to go with a sone branded usb hub. I have one for ps3x it could be cross compatible. If you cannot find a authentic Sony playstation hub, go with the powered insignia brand. The mouse does work with ps4 via usb cable. I cant say for sure with blutooth. Just a fyi the usb ports on ps4 are not good quality, I would recommend only powered 2 devices at a time.