A:Answer Michael,
The answer to your question is a bit tricky as it is more than just a simple yes or no answer. There are things that you need to consider.
The short answer to your question is no. If you buy two packs of two 16GB sticks of ram of the same brand, model, frequency, and timing, etc. to increase to 64GB of ram it will not cause any problems, however, there are a lot of caveats to that.
First question you need to ask is does your motherboard support 64GB of ram? If so, am I going to see any sort of diminishing returns for having all of my ram slots filled vs. only two of them being filled? Yes, this is an issue that has been seen with the Ryzen 3000 series processors. It has been shown that having all four ram slots filled will actually cause your ram to not function at full speed. Also take into consideration needing to have some hefty airflow in your case to cool all of that ram and those lovely led's. Does your motherboard actually support this speed of ram natively or do you have to overclock to get these speeds? This one might not be so much of a problem with some of the automatic overclocking tools coming included in the bios of a lot of motherboards in this era. However, if your motherboard doesn't have such tools this might become problematic if you are not entirely familiar with the intricacies of overclocking which could cause damage to your system.
Just a few things to take into account when deciding what, and how much, ram to get.
