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Should work. Looking at the motherboard layout, there is an M.2 slot on the lower right of the board. I've attached a picture with the slot circled. It may not work with your CPU though. This is a PCI Gen 4 drive and PCI Gen 4 wasn't supported on CPU's that would fit in this socket. It's hit or miss on whether the BIOS on the board will be able to account for this. I would recommend this drive instead as it should be guaranteed to work: https://www.bestbuy.com/site/crucial-p3-2tb-internal-ssd-pcie-gen-3-x4-nvme/6509711.p?skuId=6509711
Sorry, there was a problem. Please try again later.Hello Finch, Thank you for your question, This SSD is compatible with the system "Asus Z170Pro". Regards, Crucial
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