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Thank you for reaching out to us. This system should be compatible with an AIO (All in One) liquid cooler, however, it is always recommended that you check for compatibility before making your purchase on new hardware. If you have any further questions or concerns then please do not hesitate to give our tech support agents a call for any assistance; we're always happy to help. Tech support: (888)900-5180 -CyberpowerPC Support
Sorry, there was a problem. Please try again later.Case is very large so a water cooling system should work. There is an opening on top that looks as if it can take two 120 mm fans so I think it should be able to use a 120 or 240 mm cooler. The front has spaces for fans as well but doesn't have as much as an opening as the side vent but is open with slits to each side ... guess that can be used as well for a cooler but not as effective as the top.
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