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Hello, thank you for your question. This cable will work with your Epson Stylus NX420 only if your iMac uses a USB‑C port for connecting printers. The printer uses a USB‑B connection, and this cable converts USB‑C to USB‑B, so it can work as long as your iMac supports USB‑C. For confirmation based on your exact iMac version, you can check directly with Best Buy at 1‑888‑237‑8289. Sudeep | Insignia
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