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Thank you for your inquiry! Yes, you can use the Insignia™ USB-C to USB Adapter to connect your Nektar Impact LX49+ MIDI controller to your iMac 24" M4. The LX49+ is a USB class-compliant device, meaning it doesn't require special drivers and works seamlessly with macOS. Since your iMac uses USB-C ports, the Insignia adapter allows you to connect standard USB-A devices like your MIDI controller. The adapter supports USB 3.0 and is plug-and-play compatible with macOS, so setup should be straightforward.
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