A:AnswerI highly doubt you'd be able to get this case on with a screen protector already applied. However, the case does come with a plastic one that can be used that fits just inside the window. Also, the iPhone 6s has a screen that is extremely resilient, and takes some difficulty to scratch (not to say it's impossible, I have done it before). Perhaps the one that comes with the lifeproof would be sufficient for your trip.
A:AnswerYes. I have taken this case underwater in a swimming pool and have kept in my swimsuit pocket in a lazy river pool at a waterpark. It held up nicely with no leaks. They do recommend that you test the case under water for leaks prior to installing it on your phone just in case. Those instructions come in the box.