A:AnswerAccording to the manufacturer you can use a USB Mouse and USB keyboard with the Xbox One S. I'm not sure if there are limitations as to what brands are compatible but I do know that my USB Logitech infrared mouse worked with it. I highly recommend going to Microsoft's Xbox website with any questions you have regarding the Xbox One S simply for the reason of possible updates that may have already been made and/or updates that are scheduled for the near future.
Personally I've had great success getting answers to my questions regarding all of my Xbox's.
A:AnswerAccording to the Best Buy employee at our local store, this particular console has not been available in our local store since the Christmas holidays. In your neck-of-the- woods, it might be a different story. You can check on the Best Buy website by inputting a zip code to see if a store local to you has one in stock.